Outcomes of Other Medications on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (big route) and CYP2C9 (small route). As a result, inhibitors of those isoenzymes could lessen sildenafil clearance and inducers of these isoenzymes may perhaps enhance sildenafil clearance.While in the occasion of the erection that persists extended tha